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Appearance: White Crystalline Powder Odor and taste: Almost odorless, sour taste Arsenic (As): 2 ppm Assay: 98.0 % Heavy Metals: 10 ppm Identification (IR): Corresponds Identification (Lead Acetate): Positive Identification (Ninhydrin): Positive Iron (Fe): 10 ppm Loss on Drying: 0.5 % Melting Point: About 185 C Optical Rotation: -21 - -11 Residue on Ignition: 0.1 % Solubility: Soluble in Water Solution: Clear Solution BSE/TSE Free: BSE/TSE Free Country of Origin: Report G22010 v2 MSDS_1.pdf Download Certificate of Analysis

Reduced p27Kip-1 levels, often due to overexpression of the F-box protein Skp2, are associated with tumor progression and poor prognosis in various cancers

Animal groups The animals were split into 4 groups, including a 300 mg/kg caffeine group (CG), 50 mg/kg taxifolin + 300 mg/kg caffeine group (TCG), 2 mg/kg diazepam + 300 mg/kg caffeine group (DCG), and healthy control group (HG)

Mora et al., 2017)