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in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )

Key Research Properties: Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor Modulates NAD+ metabolism and methylation capacity Studied in context of energy expenditure and metabolic regulation NNMT is upregulated in obesity

Potential Side Effects Reported side effects may include: Injection site pain, redness, or irritation Mild diarrhea Itching or rash Headache, dizziness, and nausea Acneiform skin eruptions Hypokalemia (low potassium) see Warnings above Serious adverse reactions are uncommon but may occur