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For the GSTO1 C4-10 complex, GSTO1 (2.66 mg ml 1 ) was incubated in a 1:1.5 molar ratio with C4-10 for 24 h at 4 C then concentrated to 26.2 mg ml 1

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Mutations in mitochondrial DNA are mainly caused by the deletion of its common deletion (CD) of 4981 bp, the accumulation of which in patients might be involved in the development and progression of NPC linked with patient age and clinical stage

Medication taper and reassessment plan: If stopping semaglutide, plan a gradual transition with intensified lifestyle support and closer monitoring for three to six months