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Rare genetic diseases Transthyretin amyloidosis (ATTR) is a rare systemic disease characterized by the progressive deposition of misfolded TTR protein in the heart and peripheral nerves, leading to transthyretin amyloid polyneuropathy (ATTR-PN) and transthyretin amyloid cardiomyopathy (ATTR-CM)

HDACs are crucial epigenetic regulators of gene expression, with HDAC6 playing a role in processes such as oxidative stress, autophagy and the DNA damage response (99)

(106)demonstrated that oral administration of LGG increased the prevalence of butyrate-producing Clostridium in the gastrointestinal tract, elevated butyrate concentrations in the intestine and blood, and enhanced regulatory T cell (Treg) populations in both the gut and bone marrow