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A nasal formulation of epinephrine (Neffy ) was FDA approved in 2024 for the emergency treatment of Type 1 allergic reactions, including anaphylaxis

This sheds light on a mechanism underlying chemotherapy resistance

This suggests that TRPM2 may promote tumor progression by fostering an immunosuppressive microenvironment through M2 macrophage polarization, making it a potential target for immunotherapy in OC (149)