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Authors contributions Study concept and design (TOA, BOE, CNE, CON), acquisition of data (TOA), drafting of the manuscript (TOA, CON), critical revision of the manuscript for important intellectual content (TOA, BOE, CNE, CON), administrative, technical, or material support (BOE, CNE), and study supervision (CON)

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The upregulation of genes as TREM2, TYRO protein tyrosine kinase-binding protein (TYROBP), APOE, CD33, and membrane-spanning 4-domains, subfamily A (MS4A) detected in ALS patients (295) indicate ALS-specific microglial activation states that likely contribute to disease progression