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Phase II study of belagenpumatucel-L, a transforming growth factor -2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer

The finding underscores the need for pre-specified monitoring plans, routine competency maintenance, incident reporting, and subgroup performance auditspractical accountability mechanisms that complement efficacy trials and help prevent unintended harms during post-deployment use

The neuroprotective effects may be related to DSIP's sleep-promoting properties, as adequate slow-wave sleep is essential for brain waste clearance through the glymphatic system and neural repair processes

Similar to RFK KO and FLAD1 KO cells, we observed decreased levels of untagged FSP1 and FSP1GFP proteins and increased sensitization to ferroptosis upon GPX4 inhibition under vitamin-B2-deficient conditions (Extended Data Fig