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Circulatory symptoms You might notice breathlessness even while sitting still, a rapid heartbeat, or unusually pale skin

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Neuromelanin-sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinsons disease and its phenotypes

Because PDI bound by 4-HNE was identified in vivo, where GSH is present, it suggests that this compensatory mechanism may be limited by high levels of oxidative stress in which GSH concentrations are low [91]