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Besides, the roots can also enhance the efficiency of different delivery systems and therefore, boost the bioavailability of such potential therapeutic agents that could potentially change the results of interstitial cystitis treatment (Selyutina et al., 2016)

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Although several alternative extraction strategiessuch as ultrasound- (Ranasinghe et al., 2024), enzyme-assisted (Liu et al., 2025), and Supercritical Fluid Extraction (SFE) ( More recent literature has highlighted the emerging role of Deep Eutectic Solvents (DES), low-melting mixtures formed by hydrogen bond donors and acceptors (Hansen et al., 2021), and their natural counterparts, Natural Deep Eutectic Solvents (NADES), made from citric acid (C 6 H 8 O 7 ) and xylitol (C 5 H 12 O 5 ), as sustainable extraction media