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Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

doi: 10.3389/fcimb.2024.1416819 Received 13 April 2024 Accepted 08 July 2024 Published 31 July 2024 Volume 14 - 2024 Edited by Maurizio Sanguinetti, Catholic University of the Sacred Heart, Italy Reviewed by Diane Bimczok, Montana State University, United States Giuseppe Losurdo, University of Bari Medical School, Italy Updates Copyright 2024 Lin, Liu, Lu, Zhai and Cheng

Hepatic APAP metabolism results in the production of the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI), which under physiological conditions is cleared by its conjugation with glutathione (GSH) to prevent its targeting to mitochondria

Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-B activation and cell proliferation in human breast cancer MCF-7 cells