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NGF and its receptor TrkA are implicated in psychiatric disorders such as depression and schizophrenia, where altered brain levels of neurotrophins are commonly observed (Ciafr et al., 2020)

Residue-Specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia Coli Cell-Free Transcription-Translation System

We next determined that the memory facilitating effects of intra cerebroventricularly delivered Nle-AngIV derived from its N-terminal region given that N-directed fragments as small as tetra- and tripeptides retained the ability to overcome scopolamine-induced amnesia [2,28]

As NAD+ declines with age, sirtuin activity is reduced, compromising all downstream functions