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The longer ferroptosis induction also did not lead to increased protein levels of DPEP-1, the proposed mechanism of ferroptosis sensitization by dexamethasone at early timepoints [7] (Supplementary Fig

[2] [3] In pivotal clinical trials such as SUSTAIN for diabetes and STEP for obesity, semaglutide has achieved mean HbA1c reductions of 1.5-2.0% and body weight losses of 14.9-17.4% over 68 weeks in non-diabetic overweight or obese individuals, outperforming placebo and comparators like liraglutide through multifaceted effects on energy balance and incretin pathways

Interestingly, quercetin was shown to effectively reverse these deleterious effects

The presence of ROS stimulates the production of GSH by increasing cystine uptake and promoting the expression of GCL 34