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Recent studies have shown that the glycocalyx plays an important role in the regulation of vascular permeability, cellendothelial interactions (inflammation and coagulation) (26, 27), signaling, and molecular bioavailability (21)

A rather simple but very effective method of removing dominant epitopes to enhance responses to conserved subdominant epitopes involved the removal of the S1 portion of spike containing the RBD and then the administration of a vaccine with only S2 as a DNA vaccine or protein [73] (Table 2)