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Patients were randomized (2:1) to one of the following treatment arms: Treatment with pemetrexed continued until RECIST v1.1 (modified to follow a maximum of 10 target lesions and a maximum of 5 target lesions per organ)-defined progression of disease as determined by the investigator or unacceptable toxicity

25 , 26 Hatsugai et al demonstrated that, under proteasome regulation, the central vacuole fuses with the plasma membrane to release PELNs encapsulating defense-related proteins and hydrolytic enzymes, targeting extracellular bacterial pathogens

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