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While one of the major points of this regulation is the control of FA entry into mitochondria by malonyl-CoA-induced CPT inhibition, the availability and the redox state of FAD/FADH 2 and NAD/NADH can also play key roles in FA oxidation as they are required for the activity of acyl-CoA transferase and 3-hydroxyacyl-CoA dehydrogenase, respectively [39], two enzymes of the -oxidation

R.BlasiF.SibilaO.et al (2020)

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The challenge arises because many treatments focus only on the epidermal component, while fail to address structural dermal changes or stabilise melanocyte activity long-term