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Notch Pathway and Angiogenesis TB-500 has been shown to promote angiogenesis, likely through the Notch signalling pathway, while also organising connective tissue and preventing the appearance of myofibroblasts dual actions that distinguish it as both a pro-regenerative and anti-fibrotic research tool

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J Pharm Pharmacol 67:673684 Repka MA, Battu SK, Upadhye SB, Thumma S, Crowley MM, Zhang F, Martin C, McGinity JW (2007) Pharmaceutical applications of hot-melt extrusion: part II