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Pre-existing medical conditions can impact B12 absorption and utilization

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As we observe that STIM2, Orai1, and Orai3 proteins expressions are reduced by this treatment, reduced coupling between STIM2 and Orai more likely explains the reduced Ca 2+ entry after P 2 Y receptors activation than an inhibition of Ca 2+ release from the ER

This interaction is critical in breast cancer oncogenesis and progression, particularly as Bag-1 activity is enhanced by mutant p53, further promoting cell survival and resistance to apoptosis ( Figure 3 ) (57, 58)