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doi: 10.1210/jc.2013-2831

Practical mitigations: Warm the vial about 10 minutes before drawing Inject slowly (a 5-second push) 5 mL reconstitution (the standard for larger vials) halves the concentration and reduces concentration-dependent burn the trade-off is injecting 0.2 mL / 20 units instead of 0.1 mL / 10 units per dose Inject deeper subQ rather than intradermal the upper dermis has more mast cells and reacts more visibly Dont co-inject with NAD+

Doing so will help the serum to penetrate deeper into the inner skin layer more efficiently.

Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile