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Description

Although no single modality has been demonstrated to have superior efficacy, intralesional therapy appears to confer some benefit

Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus

10.1074/jbc.271.25.14883 121 VenmarK

Eventually, the main determinant of brain delivery efficacy is the concentration of the active (parent) drug at site of action in the brain or an increase of the relative distribution of parent drug between the brain and other tissues after administration of prodrug or nanocarriers compared to parent drug dosing