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The ginsenoside standards, Rg 1 , Re and Rb 1 were purchased from the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China), ginsenoside standards, Rf, Rg 2 , Rh 1 , Rc, Ro, Rb 2 , Rb 3 , were purchased from Shanghai Yuanye Biotechnology Co., Ltd

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Previous reports have shown that alkylating agents such as MNNG and MMS, induce an increase in phosphorylation and protein level of p53 through functional protein complexes of mismatch repair in DNA damage response [82,87]