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10.1172/JCI140100 34 EvasonK

Informed and written consent was then obtained from the Chef de zone/Mdecin de zone, who represents the interests of the ministry of health and individuals in the study population

54,55 Moreover, methylation loss at specific sites in tumor cell genomes, particularly in oncogene promoter regions, and extensive demethylation in DNA repeat sequences, undermines chromosome stability, facilitating tumor development