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Pharmaceutical Research 25 , 1902 (2008)

Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo

Moreover, an autocrine loop of MET activation has been reported in several chemoresistant cancer cell lines, leading to their increased viability [2, 28, 37]