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this effect is considered to play a crucial role in the pathogenesis of several psychiatric disorders such as depression, bipolar disorder and schizophrenia ( In recent years, dynamic disorders of mitochondria have been reported to result from mitochondrial dysfunction triggered by METH ( The regulation of mitochondrial fusion is primarily through mitofusin-1, mitofusin-2, and optic atrophy protein 1 (Opa1), whereas mitochondrial fission is regulated by mitochondrial fission 1 protein (Fis1) and dynamin-related protein 1 (Drp1) ( in vitro studies, Oxidative stress occurs primarily in mitochondria and leads to mitochondrial dysfunction by attacking mitochondria in the CNS (Xiong et al., 2017)

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Management Specific management guidelines are listed here, with details below: Stop all protein intake Provide hydration with high caloric supplementation Correct biochemical abnormalities Eliminate toxic metabolites Treat precipitating factor(s) Provide cofactor supplementation Prevent associated sequelae 1

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