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were prepared as described above

The enzyme PHD2 was therefore identified as a critical Mn sensor that controls Mn homeostasis upon Mn overload

Extracellular K + and astrocyte signaling via connexin and pannexin channels

However, with growing interest in the neurobiology of heavy metals, Mn has now been linked to other major neurodegenerative diseases such as HD and prion diseases (Martin et al., 2011