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Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability

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However, the study design has been met with plenty of criticism from the scientific communitymyself included

Ketogenic diet causes a reduction of glycolytically derived lactate in the brain due to a better tolerance to in vivo hypoxia (70)