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This process is morphologically marked by small mitochondria with condensed membrane densities, and biochemically by iron overload and GSH depletion, leading to loss of antioxidant defense and irreversible oxidative damage ( 3.2 Key molecular drivers of ferroptosis Iron Overload: Excess intracellular ferrous iron (Fe 2+ ) catalyzes the Fenton reaction, producing hydroxyl radicals (OH) that initiate lipid peroxidation cascades

doi:10.1111/j.1574-6976.2001.tb00570.x

doi: 10.1016/j.trecan.2024.10.006 190 DominguezGARoopJPoloACampisiAGabrilovichDIKumarA

However, in most cases (85%), an optic nerve glioma will not cause any problems with the child's sight or health, and is considered asymptomatic (not causing symptoms) and requires monitoring with eye examinations and MRI