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Methods: Participants (pts) with uHCC and no prior ICI therapy received STRIDE (T 300 mg + D 1500 mg [1 dose during C1] then D 1500 mg once every 4 weeks [Q4W]), T75+D (T 75 mg + D 1500 mg Q4W [4 doses] then D 1500 mg Q4W), D (1500 mg Q4W), T (750 mg Q4W [7 doses] then Q12W), or D+B (D 1120 mg + B 15 mg/kg Q3W)

However, M2 macrophages are also implicated in promoting fibrosis, potentially via TGF- production or, a topic of ongoing discussion, direct transdifferentiation into myofibroblasts [10]

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Further research is needed to optimize the efficacy and safety of these therapeutic strategies and to translate preclinical findings into clinical applications for individuals with COPD (116)