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Expected duration of vitamin B12 deficiency With proper treatment, symptoms of vitamin B 12 deficiency begin to improve within a few days

In some embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

We gratefully acknowledge the Mouse Histopathology & Phenotyping Core and the Northwestern Pathology Core, for their services