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The compound is available for purchase as a research chemical through laboratory supply vendors

Histone Deacetylase Inhibitors as Anticancer Drugs

These challenges suggest that future intervention strategies should focus more on promoting the endogenous production of SCFAs through precisely formulated soluble dietary fiber or developing butyric acid precursor drugs for colon-targeted delivery, so as to improve the efficacy and ensure the clinical safety of treatment

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD