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The inhibitory effect of mTORC1 on autophagy is induced by phosphorylating and suppressing the nuclear translocation of transcription factor EB (TFEB) 70

Consequently, Ru-hydroxide demonstrates the antioxidase-like ability to sustain stem cell viability and osteogenic differentiation in elevated ROS environments by preventing oxidative stress-induced DNA damage and cell apoptosis, thereby supporting metabolic processes, developmental pathways, osteogenesis functions, and mitigating inflammatory responses

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B-Sod2/ showed brain lipid peroxidation significantly increased, causing severe growth retardation 59