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For instance, ESM1 overexpression in the MDA-MB-231 human breast cancer cell line and mice enhances angiogenesis via the upregulation of VEGF and d-like ligand 4 (DLL4, a ligand of Notch1 in the Notch signaling) (63)

G., Huang T

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The complex nature of clinical monitoring for adverse reactions, combined with the multifaceted characteristics and elusive phenotypic thresholds of mitochondrial dysfunction, complicates our understanding of its role in various diseases