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Need for Robust Human Clinical Trials: Large-scale, randomized, placebo-controlled human clinical trials are indispensable

While A and Tau have been the main subjects of prior study, new data emphasizes mitochondrial breakdown and the ensuing oxidative stress as early, predictable events in AD pathogenesis

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Notably, we observed increased BCL-2 protein levels despite significant downregulation of Bcl-2 gene expression, suggesting complex post-transcriptional regulatory mechanisms that may include enhanced protein stability or decreased degradation in response to toxic stress