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4.1 Risks of supplement use during chemotherapy The use of natural remedies during chemotherapy in breast cancer is a compound scenario that includes the safety issue as well as drugsupplement interferences and merits meticulous assessment, because these interventionsusually considered as harmless substancesmay significantly alter the pharmacokinetic/pharmacodynamic response, antitumoural activity, and toxicity profile to conventional oncologic treatment (200)

found that histone H3K18la can also enhance the transcription of YTHDF2, and YTHDF2 can recognize m6A on PER1 and TP53 mRNA, and promote its degradation, thereby contributing to the development and progression of ocular melanoma [34]