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Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase

590 In laryngeal squamous cell carcinoma (LSCC), circPARD3 sponges miR-145-5p to activate the PRKCI-Akt-mTOR pathway and inhibit autophagy, promoting tumor cell proliferation, migration, invasion, and cisplatin resistance

While acknowledging that this was a relatively small retrospective study ( n = 81), the results suggest that in the future, pending further evidence, acetyl-l-carnitine might be considered as an addition to first-line treatments currently recommended by IASP