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The lower intracellular levels of serine and glycine in cancer cells that we observed in vitro indicate a high turnover with increased consumption and usage of these amino acids in downstream biosynthetic pathways, which is supported by the enhanced SHMT2 expression in response to RT

BIOCHEMICAL FUNCTIONS & CLINICAL RELEVANCE OF GLUTATHIONE Antioxidant Defense & Redox Regulation GSH is the most abundant intracellular antioxidant, neutralizing reactive oxygen (ROS), reactive nitrogen (RNS), and reactive sulfur (RSS) species (5-6)

Glutathione supports this process by protecting the mitochondria, which are the "powerhouses" of your cells where energy is produced

294,499,500 Thus, synbiotic therapy on intestinal microbiota has been developed as a new treatment strategy in clinical study (NCT04642482)