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Aqp4 is a key regulator of water homeostasis at the bloodbrain barrier, and its downregulation is directly associated with vasogenic edema, whereas the integrity of the extracellular matrix constrains vascular permeability and inflammatory cell infiltration

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Animal subjects were sourced from the Biogen Laboratory (Bengaluru, India) and were maintained in the animal housing facility in a controlled temperature range of 2124 0 C with a 12:12 h light-dark cycle