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For residents near Troy, MI , the answer might lie in something simpler: a Vitamin B12 deficiency

doi: 10.1155/2014/572491 Sevastre-Berghian AC, Toma VA, Sevastre B, et al

The method for vaccination according to any of claims 1293-1372, wherein the method comprises use of an administration protocol linked to age of the individual in need of said vaccine