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A subsequent trial comparing reduced glutathione to oxidized glutathione (GSSG) over 12 weeks found that both forms produced measurable skin brightening, with improvements in melanin index, UV spots, and skin wrinkles beginning at week 4 and progressing through week 12 (Weschawalit et al., 2017)

doi: 10.1016/j.gde.2016.02.007 169 VahsenNCandeCBriereJJBenitPJozaNLarochetteNet al

We used to perform depigmentation at the PA Hospital Brisbane when I was a registrar there in the early 2000s

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