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Four prominent mechanisms by which mitochondria communicate with the rest of the cell include the release of cytochrome c to induce cell death, activation of AMP-activated protein kinase (AMPK) to control mitochondrial fission and fusion, production of reactive oxygen species (ROS) to activate transcription factors, and the release of mitochondrial DNA (mtDNA) to activate immune responses 2,3,4,5 (Fig

A mathematical analysis of aerobic glycolysis triggered by glucose uptake in cones

Specifically, the cells basal OCR, maximal OCR, and spare respiratory capacity were not impacted after 24 hours of incubation with 1 M CB-839 ( Supplemental Figure 6 )