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Malabsorption of Vitamin B12 In The Small Intestine Many stomach and intestinal diseases can affect cobalamin (or vitamin B12) absorption in the small intestine

As absorption is reduced, body stores become low and a deficiency occurs Underlying diseases most commonly include: IBD (inflammatory bowel disease) Intestinal cancer (especially small cell lymphoma) Liver disease Pancreatitis and other pancreatic diseases Symptoms of low B12 levels Typically found in middle-aged or older cats that present with: Weight loss Diarrhea Vomiting Anorexia Thickened intestines In humans, B12 deficiency may also be associated with dementia, cardiovascular disease, and a certain type of anemia, although these are not specifically recognized problems in cats

The key to both diagnosis and patient management lies in determining whether the pancytopenia results from a production disorder, a consumption disorder, or a combination of both [1]