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Nammi S, Kim MS, Gavande NS, et al

Thus, the c-Met has become a major target for cancer therapy and its inhibition is currently being tested in the clinical trials [45]

bioRXiv preprint

Indeed, most of the JmjC histone demethylases identified so far are capable of efficiently catalyzing demethylation of trimethylated lysines, and in most cases, they preferentially bind the trimethylated substrates [61, 62]