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Their findings indicated that cynaroside upregulated uncoupling protein 1 (UCP-1), PPAR-, CYP7A1 and carnitine palmitoyltransferase I (CPT-1) protein expression, and downregulated C/EBP, PPAR and fatty-acid synthase (FASN) proteins to regulate lipid metabolism

The cells were cultured in DMEM with 10% fetal bovine serum and 1% (v/v) penicillin/streptomycin

This matters immensely because it means the peptide remains active in the system for a full day or more after administration, providing a constant signal for growth and repair, unlike the fleeting signal of natural IGF-1