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doi: 10.3389/fimmu.2023.1107670 Received 25 November 2022 Accepted 30 January 2023 Published 09 February 2023 Volume 14 - 2023 Edited by Jens Staal, Ghent University, Belgium Reviewed by Ping Jiang, Shanghai University of Traditional Chinese Medicine, China

Cells were fixed with paraformaldehyde 1%, permeabilized with 0.3% PBS-Triton (Sigma), saturated with normal goat serum 5% and incubated overnight with anti-CHOP primary antibody (Table S1)

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It is a skin disease characterized by flushing and burning attacks seen especially in the middle part of the face such as the nose, chin, forehead and cheeks, redness on the face, prominent capillaries, sensitivity, dryness, acne-like inflamed red bumps and sometimes growth in some tissues such as the nose