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In addition to peripheral blood mononuclear cells, also skin fibroblasts were used to derive iPSCs from Fabry patients and to differentiate these into CMs [73, 78, 80]

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The enrichment analysis of the dopaminergic neuron DEGs mainly revealed changes in ATP metabolism process, cell response to stress, motor behavior, dopaminergic synapses, dopamine neurotransmitter release cycle and long-term potential difference in the dopaminergic neurons of PD patients (Fig