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In general, the body surface area seems to have good correlation among species with several parameters including oxygen utilization, caloric expenditure, basal metabolism, blood volume and circulating plasma protein

Targeted agents like 5-HT4 agonists (tegaserod, prucalopride), guanylate cyclase-C agonists (linaclotide), and NHE3 inhibitors (tenapanor) modulate motility and pain signaling but face limitations such as side effects (e.g., diarrhea, cardiovascular risks) or insufficient long-term data