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The seven upregulated fatty acids consisted of four saturated fatty acids (i.e., myristic acid, stearic acid, palmitic acid, and eicosanoic acid) and three unsaturated fatty acids (i.e., oleic acid, 11-octadecanoic acid, and 10-undecynoic acid), while the five downregulated fatty acids included three saturated fatty acids (i.e., oxiraneundecanoic acid, oxiraneoctanoic acid, and pentanoic acid) and two unsaturated fatty acids (i.e., palmitoleic acid and 11-hexadecenoic acid) (Figure 5G)

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Hasan Khudhair D, Al-Gareeb AI, Al-Kuraishy HM, El-Kadem AH, Elekhnawy E, Negm WA, Saber S, Cavalu S, Tirla A, Alotaibi SS, Batiha GE (2022) Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury in mice by synergistic antioxidant effects