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It produces inflammation and interferes with calcium signaling, as Pb ions can mimic Ca ones, interfering with calcium-dependent processes in cells and impacting cell signaling, enzyme regulation, and muscle contraction, which are critical for airway function [117]

However, the protein abundance of the CI subunit NDUFA9 was reduced in mitochondria from adipocyte Bmal1 KO mice, while NDUFA10 and NDUFS2 were trending lower but did not reach statistical significant ( P = 0.07 and P = 0.1, respectively) (Extended Data Fig