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Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

DOI: 10.1677/JME-09-0090 Jiang, Y.J., Barish, G., Lu, B., Evans, R.M., Crumrine, D., Schmuth, M., Elias, P.M., Feingold, K.R

Oral administration of the probiotic Pediococcus pentosaceus SMM914 (SMM914) can enhance the abundance of gut probiotics and strengthen the tryptophan-melatonin pathway, increasing endogenous anti-inflammatory factors such as 6-hydroxymelatonin and secondary taurine in the lung environment, reducing the polarization of macrophages to the M1 phenotype, and finally alleviating oxidative stress in COPD mice (69)