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CD38 is also involved in gliomas where it supports the activation of tumor microglia and macrophages and subsequent tumor progression [55]

To reduce potential bias, participants were asked weekly whether they had changed their physical activity levels or habitual dietary patterns during the intervention period

the secondary outcome variables include the serum concentration of vitamin B12 (in pg/ml), adherence to treatment, quality of life (EuroQoL-5D questionnaire), patient 3satisfaction and patient preferences