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Starting at a lower dose and increasing over 2 to 3 weeks helps your body adjust

F.KunchokT.Joesch-CohenL.RosenbergD.et al (2021)

Free Radic Biol Med 2001

In this context, the distance between S atom of GPx7 Cys57 and O 1 of Gln92 is 3.1 , close enough to stabilize the thiolated GPx7 C P via a hydrogen bond to the O 1